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KMID : 0368820040430040381
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Journal of the Korean Neuropsychiatr Association
2004 Volume.43 No. 4 p.381 ~ p.385
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Monocyte Chemoattractant Protein-1(MCP1)-2518 Polymorphism and Major Depressive Disorder.
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Pae Chi-Un
Shin Yoon-Kyung
Lee Chang-Uk
Jun Tae-Youn
Kim Jung-Jin
Kim Tae-Suk
Lee Chul
Paik In-Ho
Lee Ji-Hyun
Lee Soo-Jung
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Abstract
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Object: This study was designed to examine the association between monocyte chemoattractant protein-1 (MCP1) -2518 polymorphism and major depressive disorder (MDD).
Method: Ninety patients with MDD and 114 healthy controls participated in this study. Genotyping was performed by the polymerase chain reaction-restriction fragment length polymorphism method.
Results: Genotype and allele distributions in patients with MDD were significantly different from those of the controls. In particular, subjects with the allele A were found to have an increased risk of MDD.
Conclusion: The present study suggests that the MCP1 -2518 polymorphism may have a potential role for susceptibility to MDD in the Korean population and thus calls for consecutive studies in order to pile up the data with larger different ethnic background.
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KEYWORD
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Major depressive disorder, MCP1-2518 polymorphism, Korean
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